With over 50 products in the range and Lady Gaga, Jennifer Aniston, Cate Blanchett and Victoria Beckham among its enthusiastic advocates, 111SKIN has become a beauty phenomenon with a reputation for powerful, transformative results.

But the brand was founded in 111 Harley St., by world-renowned Plastic and Reconstructive Surgeon, Dr Yannis Alexandrides and began with just one product and one clear aim: to accelerate skin healing for his patients, post-treatment and surgery. When it was discovered that the potent serum also provided dramatic anti-ageing benefits, patients began requesting bottle after bottle of the Dramatic Healing Serum that we still give to our patients today.

“We bring clinically-inspired skincare that addresses real-life concerns to our patients and customers. Using my 20+ years of expertise and medical observations, we develop products using innovative formulas that are engineered using the most sophisticated methods for efficient penetration of the skin and the highest levels of efficacy. We strive to bring the best of Harley Street to your home, creating skincare that can replicate in-clinic treatments, all while feeling opulently indulgent and a sensorial pleasure.”

Dr Yannis Alexandrides Founder of 111SKIN and renowned Plastic Surgeon

The Origins of 111SKIN

‘Always seeking ways to improve recovery in the skin after trauma or treatment, Dr Yannis collaborated with biochemical engineers to improve NAC – a precursor for glutathione production, the bodies master antioxidant and an essential component in every cell. From there, NAC Y2 was born and became the foundation of 111SKIN’s first product, now known as the Y Theorem Repair Serum. From there, the brand has grown exponentially and is now widely referred to as ‘Harley Street, bottled.’

New! Enzyme Exfoliating Cleanser


Introducing 111SKIN’s ground-breaking product, the first of it’s kind in the surgically-inspired range, the Enzyme Exfoliating Cleanser. Formed of powered of Papain Enzymes, supercharged with NAC Y²™ and more, this is the perfect way to elevate your skincare routine. Expect brighter, more even and phenomenally silky skin after one use.

The 111SKIN Collections

“Every product I develop at 111SKIN is directly inspired by my experience within the clinic. That may include patients with niche skincare concerns, a new medical delivery system or an advancement in aesthetic technology I feel I could replicate with topical application. For example, I was seeing an increase in patients struggling with acne but using harsh, inflammation-inducing products, which is why I created Clarity. By contrast, so many of my patients were benefitting from the results of Profhilo, which I wanted to replicate in our Treatment collection. It all comes back to 111 Harley St.”

Bespoke Skin Consultations

111 Harley St. offer consultations with our aestheticians to determine which collection or group of 111SKIN products are most appropriate for your skin. This can also be done via virtual consultation.

Request a Consultation

To request a surgical consultation with Dr Yannis Alexandrides MD FACS please complete this form.

Alternatively Call Us On 0344 692 1111

Our Patient Advisors are contactable via phone Monday to Friday from the hours of 10:00 – 18:00


    111 Harley St.