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111SKIN was created by Dr Yannis Alexandrides to encourage healing in the skin post-treatment and prescribed to his recovering patients following surgery. The extraordinary results and subsequent demand for the product has allowed 111SKIN to expand into 6 ranges and over 60 products. Loved by celebrities, beauty editors and skintellectuals alike, 111SKIN has gained a global presence in the luxury sector through its unusual fusion of surgical knowledge, innovative ingredients and medically-inspired delivery methods to thorough address niche skincare issues.

“We bring clinically-inspired skincare that addresses real-life concerns to our customers. Using my 20+ years of expertise and medical observations, we develop products using innovative formulas that are engineered using the most sophisticated methods for efficient penetration of the skin and the highest levels of efficacy. We strive to bring the best of Harley Street to your home, creating skincare that can replicate in-clinic treatments, all while feeling opulently indulgent and a sensorial pleasure.”

Dr Yannis Alexandrides Founder of 111SKIN and renowned Plastic Surgeon.

The Origins of 111SKIN

Always seeking ways to improve recovery in the skin after trauma or treatment, Dr Yannis collaborated with biochemical engineers to improve NAC – a precursor for glutathione production, the bodies master antioxidant and an essential component in every cell. From there, NAC Y2 was born and became the foundation of 111SKIN’s first product, now known as the Y Theorem Repair Serum. From there, the brand has grown exponentially and is now widely referred to as ‘Harley Street, bottled.’

The 111SKIN Collections

“Every product I develop at 111SKIN is directly inspired by my experience within the clinic. That may include patients with niche skincare concerns, a new medical delivery system or an advancement in aesthetic technology I feel I could replicate with topical application. For example, I was seeing an increase in patients struggling with acne but using harsh, inflammation-inducing products, which is why I created Clarity. By contrast, so many of my patients were benefitting from the results of Profhilo, which I wanted to replicate in our Treatment collection. It all comes back to 111 Harley St.”

Bespoke Skin Consultations

111 Harley St. offer consultations with our aestheticians to determine which collection or group of 111SKIN products are most appropriate for your skin. This can also be done via virtual consultation.

Request a Consultation

To request a surgical consultation with Dr Yannis Alexandrides MD FACS please complete this form.

Alternatively Call Us On 0344 692 1111

Our Patient Advisors are contactable via phone Monday to Friday from the hours of 10:00 – 18:00


    111 Harley St.
    0344 692 1111 / Book a Virtual Consultation